Over the last decade, significant progress has been made in the identification and validation
of novel biomarkers as well as refinements in the use of serum creatinine as a marker of …

Acute kidney injury is common in critically ill patients and portends a significant impact on
mortality, progressive chronic kidney disease, and cardiovascular disease and mortality …

Context. A broad range of drugs and chemicals are capable of evoking acute kidney injury,
which is conventionally determined by rising serum creatinine concentrations. However …

Drug-induced acute kidney injury (AKI), caused by renal drug metabolism, has been
regarded as a main problem in clinical pharmacology and practice. However, due to the lack …

Background/Aims: Epidemiological evidence indicates that patients with chronic kidney
diseases have increased susceptibility to adverse outcomes related to long-term exposure …

Cisplatin (CDDP) may induce nephrotoxicity through oxidative stress, DNA damage, and
inflammation. This study was performed to evaluate the antioxidant and anti-inflammatory …

This study aimed to assess the protective effect of hesperidin (HES) and rutin (RUT) against
cisplatin‐induced nephrotoxicity in male rats. Cisplatin (5 mg/kg, intraperitoneal) caused …

The aim of the present study is to assess the possible protective effects of thymol and
carvacrol against cisplatin (CP)‐induced nephrotoxicity. A single dose of CP {6 mg/kg …

Cisplatin is chemotherapeutic drug used in treatment of malignancies. However, its clinical
utility is limited by nephrotoxicity. The purpose of present study is to investigate biochemical …

Cisplatin is an anticancer agent marred by nephrotoxicity; however, limiting this adverse
effect may allow the use of higher doses to improve its efficacy. Cilastatin, a small molecule …