CRISPR/Cas9 editing of NKG2A improves the efficacy of primary CD33-directed chimeric antigen receptor natural killer cells

T Bexte, N Albinger, A Al Ajami, P Wendel… - Nature …, 2024 - nature.com
Chimeric antigen receptor (CAR)-modified natural killer (NK) cells show antileukemic activity
against acute myeloid leukemia (AML) in vivo. However, NK cell-mediated tumor killing is …

Nano/genetically engineered cells for immunotherapy

J Shen, Y Zhou, L Yin - BMEMat, 2024 - Wiley Online Library
Immunotherapy has recently emerged as a promising therapeutic modality for the treatment
of various diseases such as cancer, inflammation, autoimmune diseases, and infectious …

CAR-NK cells generated with mRNA-LNPs kill tumor target cells in vitro and in vivo

V Golubovskaya, J Sienkiewicz, J Sun, S Zhang… - International Journal of …, 2023 - mdpi.com
Natural killer (NK) cells are cytotoxic lymphocytes that are critical for the innate immune
system. Engineering NK cells with chimeric antigen receptors (CARs) allows CAR-NK cells …

CAR-NK cell therapy: a potential antiviral platform

MH Lin, LJ Hu, JS Miller, XJ Huang, XY Zhao - Science Bulletin, 2025 - Elsevier
Viral infections persist as a significant cause of morbidity and mortality worldwide.
Conventional therapeutic approaches often fall short in fully eliminating viral infections …

Engineering of potent CAR NK cells using non-viral Sleeping Beauty transposition from minimalistic DNA vectors

T Bexte, L Botezatu, C Miskey, F Gierschek, A Moter… - Molecular Therapy, 2024 - cell.com
Natural killer (NK) cells have high intrinsic cytotoxic capacity, and clinical trials have
demonstrated their safety and efficacy for adoptive cancer therapy. Expression of chimeric …

Enhancing CAR‐NK Cells Against Solid Tumors Through Chemical and Genetic Fortification with DOTAP‐Functionalized Lipid Nanoparticles

HE Shin, JH Han, JD Park, M Park… - Advanced Functional …, 2024 - Wiley Online Library
Natural killer (NK) cells are crucial in the innate immune response and show promise in
cancer immunotherapy, but face challenges in activation and targeted gene delivery. In this …

Empowering Natural Killer Cells to Combat Acute Myeloid Leukemia: Perspective on CAR-NK Cell Therapy

F Gierschek, J Schlueter, I Kühnel, FF Feigl… - Transfusion medicine …, 2024 - karger.com
Background: Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with
a high relapse rate and still limited therapeutic options. Natural killer (NK) cell-based …