Unlocking the Gates: Therapeutic Agents for Noninvasive Drug Delivery Across the Blood-Brain Barrier

C Culkins, R Adomanis, N Phan… - Molecular …, 2024 - ACS Publications
The blood-brain barrier (BBB) is a highly selective network of various cell types that acts as a
filter between the blood and the brain parenchyma. Because of this, the BBB remains a …

Blood brain barrier-on-a-chip permeation to model neurological diseases using microfluidic biosensors

P Periketi, K Kaur, FN Vaid, M Madhu, S Verma… - Journal of Knowledge …, 2024 - jklst.org
The need to understand human body functions, monitor disease progression, and advance
in drug development have consistently been major driving forces for medical innovations …

Real-time monitoring of a 3D blood–brain barrier model maturation and integrity with a sensorized microfluidic device

MC Ceccarelli, MC Lefevre, A Marino, F Pignatelli… - Lab on a Chip, 2024 - pubs.rsc.org
A significant challenge in the treatment of central nervous system (CNS) disorders is
represented by the presence of the blood–brain barrier (BBB), a highly selective membrane …

The future of biohybrid regenerative bioelectronics

A Carnicer‐Lombarte, GG Malliaras… - Advanced …, 2025 - Wiley Online Library
Biohybrid regenerative bioelectronics are an emerging technology combining implantable
devices with cell transplantation. Once implanted, biohybrid regenerative devices integrate …

Biosensor-Enhanced Organ-on-a-Chip Models for Investigating Glioblastoma Tumor Microenvironment Dynamics

G Thenuwara, B Javed, B Singh, F Tian - Sensors, 2024 - mdpi.com
Glioblastoma, an aggressive primary brain tumor, poses a significant challenge owing to its
dynamic and intricate tumor microenvironment. This review investigates the innovative …