Human female fertility and reproductive lifespan decrease significantly with age, resulting in
an extended post-reproductive period. The central dogma in human female reproduction …

The process of aging refers to physiological changes that occur to an organism as time
progresses and involves changes to DNA, proteins, metabolism, cells, and organs. Like the …

Abnormal resumption of meiosis and decreased oocyte quality are hallmarks of maternal
aging. Transcriptional silencing makes translational control an urgent task during meiosis …

Reproductive aging is a natural process conserved across species and is well-known in
females. It shows age-related follicle depletion and reduction of oocyte quality, eventually …

The cell cycle is the series of events that occur in a cell leading to its division and
duplication. It can be divided into two main stages: interphase and mitosis. Interphase is the …

Background Systemic administration of soluble factors from bone marrow–derived stem cells
combined with activated platelet-rich plasma (SC-PRP) restored ovarian function, mediated …

Background: While the term “aging” implies a process typically associated with later life, the
consequences of ovarian aging are evident by the time a woman reaches her forties, and …

DNA damage is a critical threat that poses significant challenges to all cells. To address this
issue, cells have evolved a sophisticated molecular and cellular process known as the DNA …

Aneuploidy frequently arises during human meiosis and is the primary cause of early
miscarriage and in vitro fertilization (IVF) failure. Individuals undergoing IVF exhibit …

Age-related aneuploidy in human oocytes is a major factor contributing to decreased fertility
and adverse reproductive outcomes. As females age, their oocytes are more prone to …