The BAP1 gene has emerged as a major tumor suppressor mutated with various
frequencies in numerous human malignancies, including uveal melanoma, malignant …

Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Clonal hematopoiesis results from enhanced fitness of a mutant hematopoietic stem and
progenitor cell (HSPC), but how such clones expand is unclear. We developed a technique …

The human blood system is maintained through the differentiation and massive amplification
of a limited number of long-lived haematopoietic stem cells (HSCs). Perturbations to this …

The use of blood liquid biopsy is being gradually incorporated into the clinical setting of
cancer management. The minimally invasive nature of the usage of cell-free DNA (cfDNA) …

Hematopoietic stem cells (HSC) sustain blood production over the entire life-span of an
organism. It is of extreme importance that these cells maintain self-renewal and …

Somatic mutations of ASXL1 are frequently detected in age-related clonal hematopoiesis
(CH). However, how ASXL1 mutations drive CH remains elusive. Using knockin (KI) mice …

Recent genome‐wide studies have revealed that aging or chronic inflammation can cause
clonal expansion of cells in normal tissues. Clonal hematopoiesis has been the most …

Recent high-throughput genome-wide sequencing studies have identified recurrent somatic
mutations in myeloid neoplasms. An epigenetic regulator, Additional sex combs-like 1 …

Clonal hematopoiesis (CH), the expansion of hematopoietic stem cells and their progeny
driven by somatic mutations in leukemia-associated genes, is a common phenomenon that …