Fluorinated pyrazoles play an important role in medicinal chemistry, drug discovery,
agrochemistry, coordination chemistry, and organometallic chemistry. Since the early 1990s …

Conspectus Compounds containing a difluoromethylene unit have gained increasing
attention due to their utility in drug design. Classic methods for the synthesis of these …

Cross-coupling between difluorocarbene and carbene-derived intermediates generated
from diazocompounds was developed to give gem-difluoroolefins, which constitutes a fast …

There have been significant developments in the area of perfluoroalkyl group transfer using
silicon reagents, specifically in nucleophilic trifluoromethylation. The mild and versatile …

Regioselective α, α-difunctionalization adjacent to a ketone is a significant synthetic
challenge. Here, we present a solution to this problem through the transition-metal-free …

α, α‐Difluoroketones are valuable compounds and can be used as synthetic intermediates
for the synthesis of fluorinated molecules, but they also have a direct application in …

Functional group (FG) is one of the cornerstone concepts in organic chemistry and related
areas. The wide spread of bioisosterism ideas in medicinal chemistry and beyond caused a …

Interaction of enol ethers enol acetates, enamides and enamines with fluorinated reagents
may be considered as a reliable method for the synthesis of organofluorine compounds …

A combination of (bromodifluoromethyl) trimethylsilane (Me3SiCF2Br), triphenylphosphine,
and DMPU serves as a source of difluorinated phosphorus ylide Ph3P CF2 under mild …

A reaction of bromo-and iododifluoromethyl-substituted silanes with electron-deficient
alkenes in the presence of an N-heterocyclic carbene borane complex is described. The …