Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

Activation of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is
emerging as an attractive therapeutic approach to counteract oxidative stress, inflammation …

The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …

Background Solute carrier family 7 member 11 (SLC7A11) is a component of
cysteine/glutamate transporter, which plays a key role in tumor growth; however, its …

Tight regulation of inflammation is very important to guarantee a balanced immune response
without developing chronic inflammation. One of the major mediators of the resolution of …

Cancer treatment has been always considered one of the most critical and vital themes of
clinical issues. Many approaches have been developed, depending on the type and the …

The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2–related factor 2
(NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen …

There is robust epidemiological evidence for the beneficial effects of broccoli consumption
on health, many of them clearly mediated by the isothiocyanate sulforaphane. Present in the …

Transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2) is a major regulator of
antioxidant response element‐(ARE‐) driven cytoprotective protein expression. The …

Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …