Iron participates in a wide array of cellular functions and is essential for normal neural
development and physiology. However, if inappropriately managed, the transition metal is …

Context Head injuries are risk factors for chronic depressive disorders, but this association
remains poorly explored with regards to concussion. Objectives The objective of this review …

A pressing need exists to disentangle age-related changes from pathologic
neurodegeneration. This study aims to characterize the spatial pattern and age-related …

One objective of modern neuroimaging is to identify markers that can aid in diagnosis,
disease progression monitoring and long-term drug impact analysis. In this study, Parkinson …

Normal ageing is associated with characteristic changes in brain microstructure. Although in
vivo neuroimaging captures spatial and temporal patterns of age-related changes of …

Purpose: To determine the values of iron accumulation in the basal ganglia of healthy
volunteers of different ages with R2* and raw signal intensity measurements from T1 …

Quantitative susceptibility mapping (QSM) measures bulk susceptibilities in the brain, which
can arise from many sources. In iron-rich subcortical gray matter (GM), non-heme iron is a …

Abstract Background Quantitative MRI (qMRI) techniques allow assessing cerebral tissue
properties. However, previous studies on the accuracy of quantitative T1 and T2 mapping …

Objectives We used neurite orientation dispersion and density imaging (NODDI) to quantify
changes in the substantia nigra pars compacta (SNpc) and striatum in Parkinson disease …

Cortical thickness decreases from childhood throughout life, as estimated by magnetic
resonance imaging (MRI). This monotone trajectory does not reflect the fundamentally …