Immuno‐oncology works through activation of the patient's immune system against cancer,
with several advantages over other treatment approaches, including cytotoxic agents and …

Human physiology is an ensemble of various biological processes spanning from
intracellular molecular interactions to the whole body phenotypic response. Systems biology …

Quantitative systems pharmacology models mechanistically describe a biological system
and the effect of drug treatment on system behavior. Because these models rarely are …

Background Hepatocellular carcinoma (HCC) is the most common form of primary liver
cancer and is the third-leading cause of cancer-related death worldwide. Most patients with …

Quantitative systems pharmacology (QSP) places an emphasis on dynamic systems
modeling, incorporating considerations from systems biology modeling and …

Immunotherapy has shown great potential in the treatment of cancer; however, only a
fraction of patients respond to treatment, and many experience autoimmune‐related side …

Diabetes mellitus is a major health risk in many countries, and the incidence rates are
increasing. Diverse therapeutic agents are applied to treat this condition. Since 1960 …

Background Mechanistic biosimulation can be used in drug development to form testable
hypotheses, develop predictions of efficacy before clinical trial results are available, and …

Quantitative systems pharmacology (QSP) modeling has become increasingly important in
pharmaceutical research and development, and is a powerful tool to gain mechanistic …

Cancer is a highly heterogeneous disease, exhibiting spatial and temporal variations that
pose challenges for designing robust therapies. Here, we propose the VEPART (Virtual …