Proteinase‐activated receptors (PARs) are a four‐member family of G protein‐coupled
receptors defined by their irreversible proteolytic mechanism of activation. PARs have …

Structure and dynamics of G proteins and their cognate receptors, both alone and in
complex, are becoming increasingly accessible to experimental techniques. Understanding …

Fungi do not have different sexes characterized by specific morphological organs but control
sexual development by physiological differences defined by mating types. While other …

Background Kiwi, comprising five species from the genus Apteryx, are endangered, ground-
dwelling bird species endemic to New Zealand. They are the smallest and only nocturnal …

Introduction: Kinins are main active mediators of the kallikrein–kinin system (KKS) via
bradykinin type 1 inducible (B1R) and type 2 constitutive (B2R) receptors. B2R mediates …

The CXC-chemokine receptor 6 (CXCR6) is a class A GTP-binding protein-coupled receptor
(GPCRs) that mediates adhesion of leukocytes by interacting with the transmembrane cell …

G protein-coupled receptors (GPCRs), especially the class A, are the most heavily
investigated drug targets in the pharmaceutical industry. Tremendous efforts have been …

Recent functional and proteomic studies in eukaryotes (www. openprot. org) predict the
translation of alternative open reading frames (AltORFs) in mature G-protein-coupled …

For most cell culture experiments, it is indispensable that the cells are firmly anchored to
culture plates, withstanding rinsing steps that can create shear forces and tolerating …

Over the past decades, computational methods have become invaluable for drug design
campaigns but also as auxiliary tool for structural biology. The combination of experimental …