In recent years, many compounds having potent antiviral activity in cell culture have been
detected and some of these compounds are currently undergoing either preclinical or …

In the current context of the COVID-19 pandemic, it appears that our scientific resources and
the medical community are not sufficiently developed to combat rapid viral spread all over …

Abstract HIV Transcription and Tat Protein. HIV Tat protein (A), bound to the TAR RNA stem–
loop structure, binds to the P-TEFb complex (B), activating transcriptional elongation by RNA …

The marine environment has been shown to be the source of a great diversity of chemical
structures with promising biological activities. The isolation, biological evaluation, chemical …

Cell surface heparan sulfate (HS), a polysaccharide composed of alternating uronic acid
and glucosamine residues, represents a common link that many sexually transmitted …

HIV-1 is a complex retrovirus that uses host machinery to promote its replication.
Understanding cellular proteins involved in the multistep process of HIV-1 infection may …

Pristimerin, a naturally occurring quinonemethide triterpenoid compound, is known to exert a
variety of pharmacological activities. In the present study, we investigated the molecular …

The HIV-1 transactivator Tat protein plays a key role in AIDS pathogenesis. Besides the Tat
role as activator of HIV-1 transcription, it exerts several important functions on infected and …

Protein tyrosine phosphorylation is a ubiquitous, fundamental biochemical mechanism that
regulates essential eukaryotic cellular functions. The level of tyrosine phosphorylation of …

Kaposi's sarcoma (KS), a neoplasm often associated with iatrogenic and acquired
immunosuppression, is characterized by prominent angiogenesis. Angiogenic factors …