A growing number of diseases seem to be associated with inappropriate deposition of
protein aggregates. Some of these diseases—such as Alzheimer's disease and systemic …

Prion diseases share common clinical and pathological characteristics such as spongiform
neuronal degeneration and deposition of an abnormal form of a host-derived protein, termed …

The role of autophagy in cancer onset and progression appears still controversial. On one
hand, autophagy allows cancer cell to survive in unfavorable environmental conditions, on …

Lysosomes serve dual roles in cancer metabolism, executing catabolic programs (ie,
autophagy and macropinocytosis) while promoting mTORC1-dependent anabolism …

Compartmentalization is a characterizing feature of complexity in cells, used to organize
their biochemistry. Membrane-bound organelles are most widely known, but non-membrane …

Prion diseases are caused by an unconventional infectious agent termed prion, composed
mainly of the misfolded prion protein (PrPSc). The development of highly sensitive assays …

Nosologically, transmissible spongiform encephalopathies (TSE or prion diseases) should
be grouped with other neurodegenerative disorders such as Alzheimer's and Parkinson's …

Prion diseases are transmissible, invariably fatal, neurodegenerative diseases which
include Creutzfeldt–Jakob disease (CJD) in humans and bovine spongiform …

Background The unique resistance of prions to classic methods of decontamination, and
evidence that prion diseases can be transmitted iatrogenically by medical devices pose a …

'Acridine'along with its functional analogue 'Acridone'is the most privileged pharmacophore
in medicinal chemistry with diverse applications ranging from DNA intercalators …