Recent literature suggests that the layer of adipocytes embedded in the skin below the
dermis is far from being an inert spacer material. Instead, this layer of dermal white adipose …

Proteoglycans are a specific subset of glycoproteins found at the cell surface and in the
extracellular matrix, where they interact with a plethora of proteins involved in metabolic …

Sex is an important determinant of brain microvessels (MVs) function and susceptibility to
cerebrovascular and neurological diseases, but underlying mechanisms are unclear. Using …

Background Sleep is a highly conserved behavior, yet its duration and pattern vary
extensively among species and between individuals within species. The genetic basis of …

Human induced pluripotent stem cells (hiPSCs) promise a great number of future
applications to investigate retinal development, pathophysiology and cell therapies for …

The syndecans are the major family of transmembrane proteoglycans, usually bearing
multiple heparan sulfate chains. They are present on virtually all nucleated cells of …

Objective Non-alcoholic fatty liver disease (NAFLD) is linked to impaired lipid metabolism
and systemic insulin resistance, which is partly mediated by altered secretion of liver …

Syndecan-1 (SDC-1) is a heparan sulfate (HS)/chondroitin sulfate proteoglycan (PG) of the
cell surface and the extracellular matrix (ECM), which regulates a broad spectrum of …

Heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans (PG) consist of a core
protein to which the glycosaminoglycan (GAG) chains, HS or CS, are attached through a …

Chronic kidney disease (CKD) is a major cause of death worldwide and is associated with a
high risk for cardiovascular and all-cause mortality. In CKD, endothelial dysfunction occurs …