Oxytocin and brain activity in humans: a systematic review and coordinate-based meta-analysis of functional MRI studies

SA Grace, SL Rossell, M Heinrichs… - …, 2018 - Elsevier
Oxytocin (OXT) is a neuropeptide which has a critical role in human social behaviour and
cognition. Research investigating the role of OXT on functional brain changes in humans …

The associations between oxytocin and trauma in humans: a systematic review

MF Donadon, R Martin-Santos, FL Osorio - Frontiers in pharmacology, 2018 - frontiersin.org
Studies have shown that traumatic experiences may affect hormonal systems mediated by
the hypothalamic-pituitary-adrenal (HPA) axis and the oxytocinergic system. This effect is the …

Preventing PTSD with oxytocin: effects of oxytocin administration on fear neurocircuitry and PTSD symptom development in recently trauma-exposed individuals

JL Frijling - European journal of Psychotraumatology, 2017 - Taylor & Francis
Background: Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder
which develops in approximately 10% of trauma-exposed individuals. Currently, there are …

What's Love Got to do with it: Role of oxytocin in trauma, attachment and resilience

SR Sharma, X Gonda, P Dome, FI Tarazi - Pharmacology & therapeutics, 2020 - Elsevier
Oxytocin (OT) is a neurohypophysial hormone and neuropeptide produced by the
hypothalamus and released by the pituitary gland. It has multiple physiological roles …

Intranasal peptide therapeutics: a promising avenue for overcoming the challenges of traditional CNS drug development

M Bose, G Farias Quipildor, ME Ehrlich, SR Salton - Cells, 2022 - mdpi.com
The central nervous system (CNS) has, among all organ systems in the human body, the
highest failure rate of traditional small-molecule drug development, ranging from 80–100 …

Intranasal oxytocin, but not vasopressin, augments neural responses to toddlers in human fathers

T Li, X Chen, J Mascaro, E Haroon, JK Rilling - Hormones and behavior, 2017 - Elsevier
This study investigates paternal brain function with the hope of better understanding the
neural basis for variation in caregiving involvement among men. The neuropeptides …

Intranasal oxytocin increases neural responses to social reward in post-traumatic stress disorder

L Nawijn, M van Zuiden, SBJ Koch… - Social Cognitive and …, 2017 - academic.oup.com
Therapeutic alliance and perceived social support are important predictors of treatment
response for post-traumatic stress disorder (PTSD). Intranasal oxytocin administration may …

Oxytocin curbs calorie intake via food-specific increases in the activity of brain areas that process reward and establish cognitive control

MS Spetter, GB Feld, M Thienel, H Preissl, MA Hege… - Scientific reports, 2018 - nature.com
The hypothalamic neurohormone oxytocin decreases food intake via largely unexplored
mechanisms. We investigated the central nervous mediation of oxytocin's hypophagic effect …

PTSD: past, present and future implications for China

YG Zhou, ZL Shang, F Zhang, LL Wu… - Chinese Journal of …, 2021 - mednexus.org
There has been a long history since human beings began to realize the existence of post-
traumatic symptoms. Posttraumatic stress disorder (PTSD), a diagnostic category adopted in …

Anhedonia in posttraumatic stress disorder: Prevalence, phenotypes, and neural circuitry

M Vinograd, DM Stout, VB Risbrough - … : Preclinical, translational, and …, 2021 - Springer
Anhedonia, the reduction of pleasure and reward-seeking behavior, is a transdiagnostic
construct associated with a range of important health outcomes. As with other psychiatric …