Matrix metalloproteinases (MMPs) are a group of endopeptidases that play a vital role in the
restoration of damaged skin. Through mediating various cellular events such as …

Matrix metalloproteases (MMPs) comprise a family of enzymes that cleave protein substrates
based on a conserved mechanism involving activation of an active site-bound water …

Wound healing is a dynamic process that involves a coordinated response of many cell
types representing distinct tissue compartments and is fundamentally similar among tissue …

Current in vitro gut models lack physiological relevance, and various approaches have been
taken to improve current cell culture models. For example, mimicking the three-dimensional …

1. Diabetic chronic wounds, mainly foot ulcers, constitute one of the most common
complications of poorly managed diabetes mellitus. The most typical reasons are insufficient …

The human gastrointestinal tract contains the largest population of immune cells in the body
and this is a reflection of the fact that it is continuously exposed to a myriad of dietary and …

Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …

Matrix metalloproteinases (MMPs) are an important class of enzymes in the body that
function through the extracellular matrix (ECM). They are involved in diverse …

Background Crohn's disease is characterized by repeated cycles of inflammation and
mucosal healing which ultimately progress to intestinal fibrosis. This inexorable progression …

Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the gastrointestinal
tract, encompassing two main disorders: Crohn's disease (CD) and ulcerative colitis (UC). In …