Cancers are highly complex diseases that are characterized by not only the overgrowth of
malignant cells but also an altered immune response. The inhibition and reprogramming of …

Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral
cavity. It accounts for approximately 90% of oral malignancies and impairs appearance …

Head and neck squamous cell carcinoma (HNSCC) comprises a heterogeneous group of
tumors that arise from the squamous epithelium of the oral cavity, oropharynx, larynx and …

The resistance of tumor cells to therapy severely impairs the efficacy of treatment, leading to
recurrence and metastasis of various cancers. Clarifying the underlying mechanisms of …

The tumor microenvironment (TME) chiefly consists of tumor cells and tumor-infiltrating
immune cells admixed with the stromal component. A recent clinical trial has shown that the …

Abstract Purpose: Natural killer (NK)-cell–based immunotherapy may overcome obstacles to
effective T-cell–based immunotherapy such as the presence of genomic alterations in IFN …

Summary This integrated, multiplatform PanCancer Atlas study co-mapped and identified
distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites …

Anti-programmed cell death protein 1 (PD-1) agents have become the standard of care for
platinum-refractory recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) …

Persistent infection with human papillomavirus (HPV) initiates~ 5% of all human cancers,
and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection …

Diffuse large B cell lymphoma (DLBCL) is the commonest disorder derived from the B-
lymphocytes. Inhibiting the immune checkpoint through naturalizing programmed death-1 …