Ras-GTPase-activating protein-binding protein 1 (G3BP1) is a core component and crucial
regulatory switch in stress granules (SGs). When the concentration of free RNA within cells …

The LIM domain kinases (LIMKs) are important actin cytoskeleton regulators. These
proteins, LIMK1 and LIMK2, are nodes downstream of Rho GTPases and are the key …

Abstract LIM domains kinase 2 (LIMK2) is a 72 kDa protein that regulates actin and
cytoskeleton reorganization. Once phosphorylated by its upstream activator (ROCK1) …

Abstract LIM Kinases, LIMK1 and LIMK2, have become promising targets for the
development of inhibitors with potential application for the treatment of several major …

LIMK2, a serine-specific kinase, was discovered as an actin dynamics regulating kinase.
Emerging studies have shown its pivotal role in numerous human malignancies and …

Abstract Stress granules (SGs), membrane-less cellular organelles formed via liquid-liquid
phase separation, are central to how cells adapt to various stress conditions, including …

Background Lung adenocarcinoma (LUAD) is one of the respiratory diseases with high
mortality and incidence. As an important angiogenic factor,(Endothelial cell-specific …