Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Stem cell aging and exhaustion are considered important drivers of organismal aging. Age-
associated declines in stem cell function are characterized by metabolic and epigenetic …

Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have
traditionally been linked with calorie restriction and aging in mammals. These proteins also …

Neural stem/progenitor cell (NSPC) proliferation and self‐renewal, as well as insult‐induced
differentiation, decrease markedly with age. The molecular mechanisms responsible for …

The silent mating type information regulation 2 proteins (sirtuins) 1 of class III histone
deacetylases (HDACs) have been associated with health span and longevity. SIRT1, the …

Neurologic complications are commonly regarded as irreversible impairments that stem from
limited potential of regeneration of the central nervous system (CNS). On the other side, the …

Stem cell decline is an important cellular driver of aging-associated pathophysiology in
multiple tissues. Epigenetic regulation is central to establishing and maintaining stem cell …

Adult neurogenesis in the mammalian brain is often viewed as a continuation of
neurogenesis at earlier, developmental stages. Here, we will critically review the extent to …

Highlights•Metabolism is involved in regulating NSPC quiescence versus proliferation.•
Differentiation and fate determination are associated with metabolic shifts.•Metabolism may …

Silent information regulator 1 (SIRT1) is a mammalian homolog of the nicotinamide adenine
dinucleotide (NAD)-dependent deacetylase sirtuin family. Sirtuin was originally studied as …