A fundamental question in cell biology, under investigation for over six decades, is the
structural organization of mitochondrial cristae. Long known to harbor electron transport …

Significance: Mitochondrial (mt) reticulum network in the cell possesses amazing
ultramorphology of parallel lamellar cristae, formed by the invaginated inner mitochondrial …

Mitochondrial function is critically dependent on the folding of the mitochondrial inner
membrane into cristae; indeed, numerous human diseases are associated with aberrant …

Devices that interact with living organisms are typically made of metals, silicon, ceramics,
and plastics. Implantation of such devices for long-term monitoring or treatment generally …

Endoplasmic reticulum (ER)-mitochondria contacts are critical for the regulation of lipid
transport, synthesis, and metabolism. However, the molecular mechanism and physiological …

The conserved MICOS complex functions as a primary determinant of mitochondrial inner
membrane structure. We address the organization and functional roles of MICOS and …

Among mitochondrial lipids, cardiolipin occupies a unique place. It is the only phospholipid
that is specific to mitochondria and although it is merely a minor component, accounting for …

Mitochondria are complex organelles with two membranes. Their architecture is determined
by characteristic folds of the inner membrane, termed cristae. Recent studies in yeast and …

The dynamic and fluid nature of mitochondria allows for modifications in mitochondrial
shape, connectivity and cristae architecture. The precise balance of mitochondrial dynamics …

Mitochondria play central roles in cellular energetics, metabolism and signalling. Efficient
respiration, mitochondrial quality control, apoptosis and inheritance of mitochondrial DNA …