Antibodies to combat viral infections: development strategies and progress
G Pantaleo, B Correia, C Fenwick, VS Joo… - Nature Reviews Drug …, 2022 - nature.com
Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …
viral infections owing to characteristics such as their high specificity and their ability to …
[HTML][HTML] Approaches, progress, and challenges to hepatitis C vaccine development
Risk factors for hepatitis C virus (HCV) infection vary, and there were an estimated 1.75
million new cases worldwide in 2015. The World Health Organization aims for a 90 …
million new cases worldwide in 2015. The World Health Organization aims for a 90 …
Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail
Understanding the molecular basis for immune recognition of SARS-CoV-2 spike
glycoprotein antigenic sites will inform the development of improved therapeutics. We …
glycoprotein antigenic sites will inform the development of improved therapeutics. We …
Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2
Frequent outbreaks of coronaviruses underscore the need for antivirals and vaccines that
can counter a broad range of coronavirus types. We isolated a human antibody named 76E1 …
can counter a broad range of coronavirus types. We isolated a human antibody named 76E1 …
Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail
The SARS-CoV-2 pandemic has led to an urgent need to understand the molecular basis for
immune recognition of SARS-CoV-2 spike (S) glycoprotein antigenic sites. To define the …
immune recognition of SARS-CoV-2 spike (S) glycoprotein antigenic sites. To define the …
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
TKH Scheel, CM Rice - Nature medicine, 2013 - nature.com
More than two decades of intense research has provided a detailed understanding of
hepatitis C virus (HCV), which chronically infects 2% of the world's population. This effort has …
hepatitis C virus (HCV), which chronically infects 2% of the world's population. This effort has …
The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control
J Bukh - Journal of hepatology, 2016 - Elsevier
The discovery of hepatitis C virus (HCV) in 1989 permitted basic research to unravel critical
components of a complex life cycle for this important human pathogen. HCV is a highly …
components of a complex life cycle for this important human pathogen. HCV is a highly …
A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory
L Swadling, S Capone, RD Antrobus, A Brown… - Science translational …, 2014 - science.org
A protective vaccine against hepatitis C virus (HCV) remains an unmet clinical need. HCV
infects millions of people worldwide and is a leading cause of liver cirrhosis and …
infects millions of people worldwide and is a leading cause of liver cirrhosis and …
Broadly neutralizing antiviral antibodies
D Corti, A Lanzavecchia - Annual review of immunology, 2013 - annualreviews.org
A fascinating aspect of viral evolution relates to the ability of viruses to escape the adaptive
immune response. The widely held view has been that the great variability of viral …
immune response. The widely held view has been that the great variability of viral …
Hepatitis C virus E2 envelope glycoprotein core structure
Hepatitis C virus (HCV), a Hepacivirus, is a major cause of viral hepatitis, liver cirrhosis, and
hepatocellular carcinoma. HCV envelope glycoproteins E1 and E2 mediate fusion and entry …
hepatocellular carcinoma. HCV envelope glycoproteins E1 and E2 mediate fusion and entry …