[HTML][HTML] Role and significance of c-KIT receptor tyrosine kinase in cancer: A review
Abstract c-kit is a classical proto-oncogene that encodes a receptor tyrosine kinase (RTK)
that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell …
that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell …
Folding and intrinsic disorder of the receptor tyrosine kinase KIT insert domain seen by conventional molecular dynamics simulations
The kinase insert domain (KID) of RTK KIT is the key recruitment region for downstream
signalling proteins. KID, studied by molecular dynamics simulations as a cleaved …
signalling proteins. KID, studied by molecular dynamics simulations as a cleaved …
Does Generic Cyclic Kinase Insert Domain of Receptor Tyrosine Kinase KIT Clone Its Native Homologue?
J Ledoux, L Tchertanov - International Journal of Molecular Sciences, 2022 - mdpi.com
Receptor tyrosine kinases (RTKs) are modular membrane proteins possessing both well-
folded and disordered domains acting together in ligand-induced activation and regulation …
folded and disordered domains acting together in ligand-induced activation and regulation …
The severity of MUSK pathogenic variants is predicted by the protein domain they disrupt
BT Cocanougher, SW Liu, L Francescatto… - Human Genetics and …, 2024 - cell.com
Biallelic loss-of-function variants in the MUSK gene result in two allelic disorders:(1)
congenital myasthenic syndrome (CMS; OMIM: 616325), a neuromuscular disorder that has …
congenital myasthenic syndrome (CMS; OMIM: 616325), a neuromuscular disorder that has …
The inherent coupling of intrinsically disordered regions in the multidomain receptor tyrosine kinase KIT
RTK KIT regulates a variety of crucial cellular processes via its cytoplasmic domain (CD),
which is composed of the tyrosine kinase domain, crowned by the highly flexible domains …
which is composed of the tyrosine kinase domain, crowned by the highly flexible domains …
Site-Specific Phosphorylation of RTK KIT Kinase Insert Domain: Interactome Landscape Perspectives
J Ledoux, L Tchertanov - Kinases and Phosphatases, 2023 - mdpi.com
The kinase insert domain (KID) of RTK KIT is a key recruitment region for downstream
signalling proteins (DSPs). KID, as a multisite phosphorylation region, provides alternative …
signalling proteins (DSPs). KID, as a multisite phosphorylation region, provides alternative …
Receptor Tyrosine Kinase KIT: A New Look for an Old Receptor
J Ledoux, L Tchertanov - International Work-Conference on Bioinformatics …, 2022 - Springer
RTK KIT regulates a variety of crucial cellular processes via its cytoplasmic (CD) domain
composed of the tyrosine kinase domain crowned by highly flexible domains …
composed of the tyrosine kinase domain crowned by highly flexible domains …
[PDF][PDF] Biochemische und strukturbiologische Charakterisierung der Rezeptortyrosinkinasen KIT und PDGFRA
A Teuber - d-nb.info
8PQ91 c-KIT kinase domain in complex with avapritinib 8PQA2 c-KIT kinase domain in
complex with avapritinib derivative 4 8PQB3 c-KIT kinase domain in complex with avapritinib …
complex with avapritinib derivative 4 8PQB3 c-KIT kinase domain in complex with avapritinib …
Receptor Tyrosine Kinase KIT: A New Look for an Old Receptor
L Tchertanov, J Ledoux - The 3rd Struchkov Meeting (2021) …, 2021 - hal.science
Receptor tyrosine kinases (RTKs) control various signalling pathways in cells. Their
remarkable conformational plasticity enables the specific recognition of many molecules …
remarkable conformational plasticity enables the specific recognition of many molecules …