Amidst the global shortfalls in blood supply, storage limitations of donor blood and the
availability of potential blood substitutes for transfusion applications, society has pivoted …

Living biointerfaces are a new class of biomaterials combining living cells and polymeric
matrices that can act as biologically active and instructive materials that host and provide …

Background Ex vivo haematopoietic stem/progenitor cell (HSPCs) expansion constitutes an
important area of research, and has the potential to improve access to umbilical cord blood …

Human leukocyte antigen (HLA)-matched cord blood (CB) transplantation is a procedure for
the treatment of certain hematological malignancies, hemoglobinopathies, and autoimmune …

Cord blood hematopoietic stem/progenitor cells (CB-HSPCs) have emerged as a promising
supply for functional platelets to potentially alleviate the increasing demand for platelet …

Small molecules UM171 and SR1 have already been taken into clinically-oriented protocols
for the ex vivo expansion of hematopoietic stem (HSCs) and progenitor (HPCs) cells. In …

Objective As an inhibitor of the AhR signalling pathway, StemRegenin 1 (SR1) not only
promotes the expansion of CD34+ cells but also increases CD34− cell numbers. These …

Ex vivo red blood cell (RBC) production generates unsatisfactory erythroid cells. A deep
exploration into terminally differentiated cells is required to understand the impairments for …

Macrophages play central roles in immunity, wound healing, and homeostasis-a functional
diversity that is underpinned by varying developmental origins. The impact of ontogeny on …

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