Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials

CM Zipser, JJ Cragg, JD Guest, MG Fehlings… - The Lancet …, 2022 - thelancet.com
Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …

Characterizing natural recovery after traumatic spinal cord injury

S Kirshblum, B Snider, F Eren, J Guest - Journal of neurotrauma, 2021 - liebertpub.com
The predominant tool used to predict outcomes after traumatic spinal cord injury (SCI) is the
International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI), in …

Predicting outcomes after spinal cord injury

W Chay, S Kirshblum - Physical Medicine and Rehabilitation …, 2020 - pmr.theclinics.com
Jane Doe is a 66-year-old woman who was involved in a motor vehicle crash where she
sustained a T6 burst fracture. She underwent T5-7 laminectomy and posterior spinal fusion …

Updated review: the steroid controversy for management of spinal cord injury

JA Canseco, BA Karamian, DR Bowles… - World neurosurgery, 2021 - Elsevier
Background Acute spinal cord injury (ASCI) is a devastating event that can have a profound
impact on the lives of patients and their families. While no definitive medical treatment exists …

[HTML][HTML] A study of probable benefit of a bioresorbable polymer scaffold for safety and neurological recovery in patients with complete thoracic spinal cord injury: 6 …

KD Kim, KS Lee, D Coric, JJ Chang, JS Harrop… - … of Neurosurgery: Spine, 2021 - thejns.org
OBJECTIVE The aim of this study was to evaluate whether the investigational Neuro-Spinal
Scaffold (NSS), a highly porous bioresorbable polymer device, demonstrates probable …

[HTML][HTML] Acute implantation of a bioresorbable polymer scaffold in patients with complete thoracic spinal cord injury: 24-month follow-up from the INSPIRE study

KD Kim, KS Lee, D Coric, JS Harrop, N Theodore… - …, 2022 - journals.lww.com
BACKGROUND: Based on 6-month data from the InVivo Study of Probable Benefit of the
Neuro-Spinal Scaffold for Safety and Neurological Recovery in Patients with Complete …

The damaged spinal cord is a suitable target for stem cell transplantation

A Curt, J Hsieh, M Schubert, M Hupp… - … and neural repair, 2020 - journals.sagepub.com
Background. Given individuals with spinal cord injury (SCI) approaching 2 million, viable
options for regenerative repair are desperately needed. Human central nervous system stem …

Duroplasty for injured cervical spinal cord with uncontrolled swelling: protocol of the DISCUS randomized controlled trial

S Saadoun, L Grassner, M Belci, J Cook, R Knight… - Trials, 2023 - Springer
Background Cervical traumatic spinal cord injury is a devastating condition. Current
management (bony decompression) may be inadequate as after acute severe TSCI, the …

Clinical trials using mesenchymal stem cells for spinal cord injury: Challenges in generating evidence

LT de Araújo, CT Macêdo, PKF Damasceno… - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) remains an important public health problem which often causes
permanent loss of muscle strength, sensation, and function below the site of the injury …

Predictive value of midsagittal tissue bridges on functional recovery after spinal cord injury

D Pfyffer, K Vallotton, A Curt… - … and neural repair, 2021 - journals.sagepub.com
Background The majority of patients with spinal cord injury (SCI) have anatomically
incomplete lesions and present with preserved tissue bridges, yet their outcomes vary …