Hypothalamic syndrome
Hypothalamic syndrome (HS) is a rare disorder caused by disease-related and/or treatment-
related injury to the hypothalamus, most commonly associated with rare, non-cancerous …
related injury to the hypothalamus, most commonly associated with rare, non-cancerous …
Genetic regulation of pituitary gland development in human and mouse
Normal hypothalamopituitary development is closely related to that of the forebrain and is
dependent upon a complex genetic cascade of transcription factors and signaling molecules …
dependent upon a complex genetic cascade of transcription factors and signaling molecules …
Mutations in human accelerated regions disrupt cognition and social behavior
Comparative analyses have identified genomic regions potentially involved in human
evolution but do not directly assess function. Human accelerated regions (HARs) represent …
evolution but do not directly assess function. Human accelerated regions (HARs) represent …
What is trophoblast? A combination of criteria define human first-trimester trophoblast
Controversy surrounds reports describing the derivation of human trophoblast cells from
placentas and embryonic stem cells (ESC), partly due to the difficulty in identifying markers …
placentas and embryonic stem cells (ESC), partly due to the difficulty in identifying markers …
The genetic architecture of microphthalmia, anophthalmia and coloboma
KA Williamson, DR FitzPatrick - European journal of medical genetics, 2014 - Elsevier
Microphthalmia, anophthalmia and coloboma (MAC) are distinct phenotypes that represent
a continuum of structural developmental eye defects. In severe bilateral cases …
a continuum of structural developmental eye defects. In severe bilateral cases …
Genetics of combined pituitary hormone deficiency: roadmap into the genome era
Q Fang, AS George, ML Brinkmeier… - Endocrine …, 2016 - academic.oup.com
The genetic basis for combined pituitary hormone deficiency (CPHD) is complex, involving
30 genes in a variety of syndromic and nonsyndromic presentations. Molecular diagnosis of …
30 genes in a variety of syndromic and nonsyndromic presentations. Molecular diagnosis of …
Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors
The continuously growing mouse incisor serves as a valuable model to study stem cell
regulation during organ renewal. Epithelial stem cells are localized in the proximal end of …
regulation during organ renewal. Epithelial stem cells are localized in the proximal end of …
Intertwined signaling pathways governing tooth development: a give-and-take between canonical Wnt and Shh
F Hermans, L Hemeryck, I Lambrichts… - Frontiers in cell and …, 2021 - frontiersin.org
Teeth play essential roles in life. Their development relies on reciprocal interactions
between the ectoderm-derived dental epithelium and the underlying neural crest-originated …
between the ectoderm-derived dental epithelium and the underlying neural crest-originated …
Septo-optic dysplasia
EA Webb, MT Dattani - European Journal of Human Genetics, 2010 - nature.com
This review summarises the key clinical features of septo-optic dysplasia (SOD), the
significant inroads that progress in genetics has made into our understanding of the …
significant inroads that progress in genetics has made into our understanding of the …
Complex architecture and regulated expression of the Sox2ot locus during vertebrate development
The Sox2 gene is a key regulator of pluripotency embedded within an intron of a long
noncoding RNA (ncRNA), termed Sox2 overlapping transcript (Sox2ot), which is transcribed …
noncoding RNA (ncRNA), termed Sox2 overlapping transcript (Sox2ot), which is transcribed …