[HTML][HTML] Genetics of osteoarthritis

G Aubourg, SJ Rice, P Bruce-Wootton… - Osteoarthritis and …, 2022 - Elsevier
Osteoarthritis genetics has been transformed in the past decade through the application of
large-scale genome-wide association scans. So far, over 100 polymorphic DNA variants …

The other side of the coin: mesenchymal stromal cell immortalization beyond evasion of senescence

LS Lenz, MR Wink - Human Cell, 2023 - Springer
Mesenchymal stromal cells (MSC) are promising options to cellular therapy to several
clinical disorders, mainly because of its ability to immunomodulate and differentiate into …

Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells

A Rodríguez Ruiz, A Dicks, M Tuerlings… - Cell and Tissue …, 2021 - Springer
Cartilage has little intrinsic capacity for repair, so transplantation of exogenous cartilage
cells is considered a realistic option for cartilage regeneration. We explored whether human …

Transient receptor potential vanilloid 4 as a regulator of induced pluripotent stem cell chondrogenesis

VP Willard, HA Leddy, D Palmer, CL Wu, W Liedtke… - Stem Cells, 2021 - academic.oup.com
Transient receptor potential vanilloid 4 (TRPV4) is a polymodal calcium-permeable cation
channel that is highly expressed in cartilage and is sensitive to a variety of extracellular …

Ginsenoside Rg1/ADSCs supplemented with hyaluronic acid as the matrix improves rabbit temporomandibular joint osteoarthrosis

Y Guo, T Tian, S Yang, Y Cai - Biotechnology and Genetic …, 2023 - Taylor & Francis
Objective: To investigate whether and how ginsenoside Rg1/ADSCs supplemented with
hyaluronic acid as the matrix can improve rabbit temporomandibular joint osteoarthrosis …

[HTML][HTML] TRPV4 activation enhances compressive properties and glycosaminoglycan deposition of equine neocartilage sheets

C López-Jiménez, LLY Chiu, SD Waldman… - … and Cartilage Open, 2022 - Elsevier
Objective To evaluate the effect of Transient Receptor Potential Vanilloid 4 (TRPV4) cation
channel modulation on mesenchymal stromal cell (MSC)-derived neocartilage. Methods RT …

Single nucleotide editing at the 11q23. 3 adiposity risk locus by the prime editing technique

IJ Petersen - 2024 - bora.uib.no
Unraveling the mysteries hidden within the small fraction of the genome that makes every
human unique, is still ongoing. Most of these genetic variations require interactions with …

Dynamic hypoxic pre-conditioning of cells seeded in tissue-engineered scaffold to improve neovascularisation

JOY Ho - 2023 - discovery.ucl.ac.uk
Introduction: Tissue engineering (TE) is the potential solution to the global shortage of tissue
and organs. However, the lack of adequate angiogenesis to TE scaffolds during the initial …

Implementation of the 3R principle in musculoskeletal research–Refinement measures and in vitro replacement methods

A Lang - 2022 - refubium.fu-berlin.de
Musculoskeletal disorders are a challenging clinical problem. Each year, millions of patients
worldwide experience bone fractures and 10–15% of these fractures suffer from impaired …

Abatacept en pacientes con artritis reumatoide y enfermedad pulmonar intersticial

C Fernández Díaz - 2021 - repositorio.unican.es
Estudio multicéntrico abierto retrospectivo de 263 pacientes con Artritis reumatoide y
enfermedad pulmonar intersticial (AR-EPID) tratada con al menos 1 dosis de abatacept …