The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …

The discovery of cancer immune surveillance and immunotherapy has opened up a new era
of cancer treatment. Immunotherapies modulate a patient's immune system to specifically …

Type I interferon (IFN) response is commonly recognized as the main signaling activity of
STING. Here, we generate the Sting1 S365A/S365A mutant mouse that precisely ablates …

Cancer cells initiate an innate immune response by synthesizing and exporting the small-
molecule immunotransmitter cGAMP, which activates the anti-cancer Stimulator of Interferon …

Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) expression correlates with
poor prognosis in many cancers, and we previously discovered that ENPP1 is the dominant …

Cell‐autonomous sensing of nucleic acids is essential for host defence against invading
pathogens by inducing antiviral and inflammatory cytokines. cGAS has emerged in recent …

Newly emerging roles of LRRC8 volume-regulated anion channels (VRAC) raise important
questions about the therapeutic potential of VRAC in the treatment of epilepsy, type 2 …

Administration of exogenous CDNs to activate the cGAMP-STING pathway is a promising
therapeutic strategy to unleash the full potential of cancer immunotherapy. This strategy …

The biology of the immune second messenger cGAMP depends on its cellular localization.
cGAMP, which is synthesized in response to cytosolic double-stranded DNA, also exists in …

Second messengers are small molecules that orchestrate cellular changes in the face of
altered environmental conditions. Signal transduction is mediated through the action of …