The ability of a virus to spread between individuals, its replication capacity and the clinical
course of the infection are macroscopic consequences of a multifaceted molecular …

Crosslinking mass spectrometry (crosslinking-MS) is a versatile tool providing structural
insights into protein conformation and protein-protein interactions. Its medium-resolution …

Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …

Protein structure prediction is an interdisciplinary research topic that has attracted
researchers from multiple fields, including biochemistry, medicine, physics, mathematics …

Cross-linking mass spectrometry has become an established technology to provide
structural information on the topology and dynamics of protein complexes. Readily …

Elucidating protein–protein interaction (PPI) networks and their structural features within
cells is central to understanding fundamental biology and associations of cell phenotypes …

Combining diverse experimental structural and interactomic methods allows for the
construction of comprehensible molecular encyclopedias of biological systems. Typically …

In 2021, the release of AlphaFold2-the DeepMind's machine-learning protein structure
prediction program-revolutionized structural biology. Results of the CASP14 contest were an …

Replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strongly
affects cellular metabolism and results in rapid development of the cytopathic effect (CPE) …

Biological systems have evolved to utilize proteins to accomplish nearly all functional roles
needed to sustain life. A majority of biological functions occur within the crowded …