Controlling the spread of antimalarial drug resistance, especially resistance of P lasmodium
falciparum to artemisinin‐based combination therapies, is a high priority. Available data …

Malaria represents one of the most serious threats to human health worldwide, and
preventing and curing this parasitic disease still depends predominantly on the …

Should ACTs fail, no suitable alternatives exist as first-line treatments of P. falciparum
malaria. Intensified efforts are essential to monitor the spread of resistance, define …

Ca2+ channels regulate many crucial processes within cells and their abnormal activity can
be damaging to cell survival, suggesting that they might represent attractive therapeutic …

The recent reports of artemisinin (ART) resistance in the Thai–Cambodian border area raise
a serious concern on the long‐term efficacy of ARTs. To elucidate the resistance …

Across the globe, over 200 million annual malaria infections result in up to 660,000 deaths,
77% of which occur in children under the age of five years. Although prevention is important …

Despite a significant decline in morbidity and mortality over the last two decades, in 2018
there were 228 million reported cases of malaria and 405000 malaria-related deaths …

Emergence of artemisinin resistance in Cambodia highlights the importance of
characterizing resistance to this class of drugs. Previously, intermediate levels of resistance …

The sarco/endoplasmic reticulum calcium ATPase (SERCA), which plays a key role in the
maintenance of Ca2+ ion homeostasis, is an extensively studied enzyme, the inhibition of …

The definition of artemisinin resistance is becoming one of a prolonged parasite clearance
phenotype, although this variable is a complex function of both host and parasite …