Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

Lipoprotein lipase (LPL) is a rate-limiting enzyme that catalyzes hydrolysis of the triglyceride
(TG) core of circulating TG-rich lipoproteins including chylomicrons (CM), low-density …

Despite the human brain being made of nearly 60% fat, the vast majority of studies on the
mechanisms of neuronal communication which underpin cognition, memory and learning …

In recent years, the number of studies implicating lipids in the regulation of synaptic vesicle
exocytosis has risen considerably. It has become increasingly clear that lipids such as …

The contribution of progenitor subtypes to generating the billions of neurons produced
during human cortical neurogenesis is not well understood. We developed the cortical …

Parkinson's disease (PD) is a chronic disorder that presents a range of premotor signs, such
as sleep disturbances and cognitive decline, which are key non-motor features of the …

Cholesterol metabolism in the brain plays a crucial role in normal physiological function, and
its aberrations are associated with cognitive dysfunction. The present study aimed to …

We have previously reported that presynaptic dysfunction and cognitive decline have been
found in lipoprotein lipase (LPL) deficient mice, but the mechanism remains to be …

In the central nervous system (CNS), γ–aminobutyric acid A (GABAA) receptors mediate two
types of inhibitory effects. Phasic inhibition involves the activation of synaptic GABAA …

The plasma membrane of neurons acts as a critical interface underpinning intercellular
communication. Accordingly, the protein and lipid composition of the neuronal membrane is …