Regulated exocytosis of secretory granules or dense-core granules has been examined in
many well-characterized cell types including neurons, neuroendocrine, endocrine, exocrine …

Endocrine pituitary cells are neuronlike; they express numerous voltage-gated sodium,
calcium, potassium, and chloride channels and fire action potentials spontaneously …

Although cell culture studies have implicated the presence of vesicle proteins in mediating
the release of glutamate from astrocytes, definitive proof requires the identification of the …

In pituitary gonadotropes, gonadotropin-releasing hormone (GnRH) induces the rhythmic
release of Ca2+ from an inositol 1, 4, 5-trisphosphate (IP3)-sensitive store. Simultaneous …

Astrocytes, a subtype of glial cells, have numerous characteristics that were previously
considered exclusive for neurons. One of these characteristics is a cytosolic [Ca2+] …

We have used whole-cell and perforated-patch recording techniques to characterize volume-
sensitive Cl-channels in T and B lymphocytes. Positive transmembrane osmotic pressure …

There is accumulating evidence that small GTPases of the rab family regulate intracellular
vesicle traffic along biosynthetic and endocytotic pathways in eukaryotic cells. It has been …

Abstract LOW-MOLECULAR-WEIGHT GTP-binding proteins (small G proteins) of the Rab
family have been proposed to act as central regulators of vesicular traffic1, 2, and proteins of …

We have used single gonadotropes from the newly derived line, LbetaT2, to investigate the
modulation of Ca2+ signaling and exocytosis by the steroid hormone environment. This cell …

T hE fusion pore is the molecular structure that transiently connects the lumens of two
membrane compartments during their fusion. The fusion of membrane compartments occurs …