Targeting Sirt1, AMPK, Nrf2, CK2, and soluble guanylate cyclase with nutraceuticals: a practical strategy for preserving bone mass

MF McCarty, L Lewis Lujan, S Iloki Assanga - International Journal of …, 2022 - mdpi.com
There is a vast pre-clinical literature suggesting that certain nutraceuticals have the potential
to aid the preservation of bone mass in the context of estrogen withdrawal, glucocorticoid …

[HTML][HTML] Polycystic ovary syndrome pathophysiology: integrating systemic, CNS and circadian processes

G Anderson - Frontiers in Bioscience-Landmark, 2024 - imrpress.com
The conceptualization of polycystic ovary syndrome (PCOS) has primarily focused on
hormonal alterations driven by changes within the hypothalamus and ovarian granulosa …

Potent carotenoid astaxanthin expands the anti-cancer activity of cisplatin in human prostate cancer cells

Y Erzurumlu, D Catakli, HK Dogan - Journal of Natural Medicines, 2023 - Springer
Prostate cancer (PCa) is the second most common type of cancer and the sixth cause of
death in men worldwide. Radiotherapy and immunotherapy are commonly used in treating …

Novel combination therapy of prostate cancer cells with arsenic trioxide and flutamide: An in-vitro study

A Mirzaei, MR Akbari, SST Zadeh, F Khatami… - Tissue and Cell, 2022 - Elsevier
Objective The study objective was to assess the therapeutic potential of Arsenic Trioxide
(ATO) and Flutamide combination for metastatic prostate cancer (PCa) treatment. Material …

Effects of Isoflavone-Rich NADES Extract of Pueraria lobata Roots and Astaxanthin-Rich Phaffia rhodozyma Extract on Prostate Carcinogenesis in Rats

AL Semenov, ML Tyndyk, JD Von, ED Ermakova… - Plants, 2023 - mdpi.com
Prostate cancer (PCa) is one of the most common male malignancies worldwide. In the
current study, we evaluated the effects of a natural deep eutectic solvent (NADES) extract of …

High levels of follicular fluid testosterone could impair oocyte developmental competency via affecting aryl hydrocarbon receptor pathway in PCOS patients

F Eini, MA Kutenaei, T Foroutan, E Salehi - BMC Molecular and Cell …, 2022 - Springer
Background Although hormonal and metabolic dysfunction have been recognized as a
possible cause of polycystic ovarian syndrome (PCOS), the associations between …

Nutraceutical Prevention of Diabetic Complications—Focus on Dicarbonyl and Oxidative Stress

MF McCarty, JJ DiNicolantonio, JH O'Keefe - Current Issues in Molecular …, 2022 - mdpi.com
Oxidative and dicarbonyl stress, driven by excess accumulation of glycolytic intermediates in
cells that are highly permeable to glucose in the absence of effective insulin activity, appear …

Antiandrogenic Effects of a Polyphenol in Carex kobomugi through Inhibition of Androgen Synthetic Pathway and Downregulation of Androgen Receptor in Prostate …

Y Kudo, S Endo, M Tanio, T Saka, R Himura… - International journal of …, 2022 - mdpi.com
Prostate cancer (PC) represents the most common cancer disease in men. Since high levels
of androgens increase the risk of PC, androgen deprivation therapy is the primary treatment; …

Androgen Signaling in Prostate Cancer: When a Friend Turns Foe

SK Pandey, U Sabharwal, S Tripathi… - … Metabolic & Immune …, 2025 - benthamdirect.com
Androgen (AR) signaling is the main signaling for the development of the prostate and its
normal functioning. AR is highly specific for testosterone and dihydrotestosterone …

Astaxanthin: a novel antioxidant for polycystic ovary syndrome?

S Xu, Y Liu, Y Zhang, L Wang, N Ling, H Xu, Y Zhou - Discover Medicine, 2024 - Springer
Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder and the most
prevalent gynecological condition among women of reproductive age. Current treatment …