Cohesin folds the genome in dynamic chromatin loops and holds the sister chromatids
together. NIPBL Scc2 is currently considered the cohesin loader, a role that may need …

Chromosome structure regulates DNA-templated processes such as transcription of genes.
Dynamic changes to chromosome structure occur during development and in disease …

Cohesin organizes the genome through the formation of chromatin loops. NIPBL activates
cohesin's ATPase and is essential for loop extrusion, but its requirement for cohesin loading …

Cohesin regulates gene expression through context-specific chromatin folding mechanisms
such as enhancer–promoter looping and topologically associating domain (TAD) formation …

CpG methylation is one the most predominant epigenetic modification that has been
recognized as a molecular-level biomarker for various human diseases. Taking advantage …

Neural type–specific expression of clustered Protocadherin (Pcdh) proteins is essential for
the establishment of connectivity patterns during brain development. In mammals …

The cohesin complex is critical for genome organization and regulation, relying on
specialized co-factors to mediate its diverse functional activities. Here, by analyzing patterns …

Cohesin rings interact with DNA and modulate the expression of thousands of genes. NIPBL
loads cohesin onto chromosomes, and WAPL takes it off. Haploinsufficiency for NIPBL …

Myeloid leukemia associated with Down syndrome (ML-DS) has a unique molecular
landscape that differs from other subtypes of acute myeloid leukemia. ML-DS is often …

Cornelia de Lange syndrome (CdLS) is a rare, dominantly inherited multisystem
developmental disorder. Pathogenic variants in genes encoding the structural subunits and …