[HTML][HTML] Pharmacological effects and clinical prospects of cepharanthine

D Liang, Q Li, L Du, G Dou - Molecules, 2022 - mdpi.com
Cepharanthine is an active ingredient separated and extracted from Stephania cepharantha
Hayata, a Menispermaceae plant. As a bisbenzylisoquinoline alkaloid, cepharanthine has …

[HTML][HTML] A critical review: traditional uses, phytochemistry, pharmacology and toxicology of Stephania tetrandra S. Moore (Fen Fang Ji)

Y Jiang, M Liu, H Liu, S Liu - Phytochemistry Reviews, 2020 - Springer
Abstract Stephania tetrandra S. Moore (S. tetrandra) is distributed widely in tropical and
subtropical regions of Asia and Africa. The root of this plant is known in Chinese as “Fen …

Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines

S Yan, C Huang, S Wu, M Yin - Toxicology in vitro, 2010 - Elsevier
Apoptotic effects of oleanolic acid (OA) and ursolic acid (UA) on human liver cancer HepG2,
Hep3B, Huh7 and HA22T cell lines were examined. OA or UA at 2, 4, 8μmol/L were used …

Apoptotic effects of protocatechuic acid in human breast, lung, liver, cervix, and prostate cancer cells: potential mechanisms of action

MC Yin, CC Lin, HC Wu, SM Tsao… - Journal of agricultural …, 2009 - ACS Publications
Apoptotic effects of protocatechuic acid (PCA) at 1, 2, 4, 8 μmol/L on human breast cancer
MCF7 cell, lung cancer A549 cell, HepG2 cell, cervix HeLa cell, and prostate cancer LNCaP …

[HTML][HTML] Pharmacological activity of cepharanthine

K Liu, B Hong, S Wang, F Lou, Y You, R Hu, A Shafqat… - Molecules, 2023 - mdpi.com
Cepharanthine, a natural bisbenzylisoquinoline (BBIQ) alkaloid isolated from the plant
Stephania Cephalantha Hayata, is the only bisbenzylisoquinoline alkaloid approved for …

Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions

M Rogosnitzky, R Danks - Pharmacological reports, 2011 - Springer
Cepharanthine (CEP) is a naturally occurring alkaloid extracted from the plant Stephania
cepharantha Hayata. It has been widely used in Japan for more than 40 years to treat a wide …

[HTML][HTML] Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway

Y Lu, C Zhu, Y Ding, B Wang, S Zhao, J Lv… - Cell Death …, 2023 - nature.com
Cepharanthine (CEP), a bioactive compound derived from Stephania Cephalantha Hayata,
is cytotoxic to various malignancies. However, the underlying mechanism of gastric cancer is …

Tetrandrine and cepharanthine induce apoptosis through caspase cascade regulation, cell cycle arrest, MAPK activation and PI3K/Akt/mTOR signal modification in …

W Xu, X Wang, Y Tu, H Masaki, S Tanaka… - Chemico-biological …, 2019 - Elsevier
Tetrandrine (TET) and cepharanthine (CEP) are two bisbenzylisoquinoline alkaloids
isolated from the traditional herbs. Recent molecular investigations firmly supported that TET …

Molecular mechanisms and therapeutic implications of tetrandrine and cepharanthine in T cell acute lymphoblastic leukemia and autoimmune diseases

W Xu, S Chen, X Wang, S Tanaka, K Onda… - Pharmacology & …, 2021 - Elsevier
Inappropriately activated T cells mediate autoimmune diseases and T cell acute
lymphoblastic leukemia (T-ALL). Glucocorticoid and chemotherapeutic agents have largely …

The effects of biscoclaurine alkaloid cepharanthine on mammalian cells: implications for cancer, shock, and inflammatory diseases

S Furusawa, J Wu - Life sciences, 2007 - Elsevier
The extract of Stephania cepharantha Hayata contains biscoclaurine alkaloids such as
cepharanthine, which have been used widely in Japan for the treatment of patients with …