Cartilage is an avascular tissue and cartilage metabolism depends on molecule diffusion
from synovial fluid and subchondral bone. Thus, nutrient availability is limited by matrix …

The homeostasis of the vertebrate body depends on anabolic and catabolic activities that
are closely linked the inside and outside of the cell. Lipid metabolism plays an essential role …

Osteoarthritis (OA) is a multifaceted musculoskeletal disorder, with a high prevalence
worldwide. Articular cartilage and synovial membrane are among the main biological targets …

Osteoarthritis (OA) is one of the most common degenerative joint diseases, often involving
the entire joint. The degeneration of articular cartilage is an important feature of OA, and …

The objective of this study was to explore the effects of intermittent hydrostatic pressure (IHP)
on the chondrogenic differentiation of cartilage progenitor cells (CPC s) cultivated in alginate …

Background Mesenchymal stromal cells attract much interest in tissue regeneration because
of their capacity to differentiate into mesodermal origin cells, their paracrine properties and …

Background Mechanical stimulation is necessary for regulating correct formation of the
skeleton. Here we test the hypothesis that mechanical stimulation of the embryonic skeletal …

The regeneration of large bone defects remains clinically challenging. The aim of our study
was to use a rat model to use nasal chondrocytes to engineer a hypertrophic cartilage tissue …

Limited supplies of healthy autologous or allogeneic cartilage sources have inspired a
growing interest in xenogeneic cartilage matrices as biological scaffolds for cartilage tissue …

Lipids affect cartilage growth, injury, and regeneration in diverse ways. Diet and metabolism
have become increasingly important as the prevalence of obesity has risen. Proper lipid …