With the advent of high-throughput molecular technologies, several precision medicine (PM)
studies are currently ongoing that include molecular screening programs and PM clinical …

Molecular profiling provides the insight that specific genetic alterations can be detected
across a wide range of different histologically characterised tumour types. Thus, the basic …

Background Overexpression of fibroblast growth factor receptor 1 (FGFR1), found in≤ 8% of
hormone receptor–positive (HR+), human epidermal growth factor receptor 2–negative …

A better understanding of cancer biology has led to the development of molecular targeted
therapy, which has dramatically improved the outcome of some cancer patients, especially …

Background Several studies used the ratio of progression-free survival (PFS) on genotype-
matched treatment to PFS on genotype-unmatched treatment to assess the efficacy of …

Causing a fifth of all disease burden in the region1, the incidence of cancer across Europe
has increased from around two million to three million cases since the end of the last decade …

In therapeutic research, the safety and efficacy of pharmaceutical products are necessarily
tested on humans via clinical trials after an extensive and expensive preclinical …

The SHIVA trial compared the efficacy of targeted agents selected on the basis of tumour
molecular profiling (using an algorithmic approach) with that of physician's choice across …

Background: Cervical cancer (CC) remains a leading cause of gynaecological cancer-
related mortality worldwide. CC pathogenesis is triggered when human papillomavirus …

Purpose There is variability in utilization of Comprehensive Genomic Profiling (CGP) in most
of the metastatic solid tumors (MST). We evaluated the CGP utilization patterns and its …