WNT-signaling controls important cellular processes throughout embryonic development
and adult life, so any deregulation of this signaling can result in a wide range of pathologies …

Wnt/β-catenin signaling is a highly conserved pathway that regulates cell proliferation,
differentiation, apoptosis, stem cell self-renewal, tissue homeostasis, and wound healing …

Several signaling pathways have been identified as important for developmental processes.
One of such important cascades is the Wnt/β‐catenin signaling pathway, which can regulate …

Colorectal cancer (CRC) is one of the most common malignant tumor types occurring in the
digestive system. The incidence of CRC has exhibits yearly increases and the mortality rate …

Aberrant activation of the Wnt/β‐catenin signaling circuit is associated with cancer
recurrence and relapse, cancer invasion and metastasis, and cancer immune evasion …

Loss of the B2M gene is associated with tumour immune escape and resistance to
immunotherapy. However, genetic alterations of the B2M gene are rare. We performed an …

The response of patients with recurrent glioblastoma multiforme to neoadjuvant immune
checkpoint blockade has been challenging to interpret due to the inter-patient and intra …

Tankyrases are multifunctional poly (adenosine diphosphate-ribose) polymerases that
regulate diverse biological processes including telomere maintenance and cellular …

Wnt signaling plays numerous functions in cancer, from primary transformation and tumor
growth to metastasis. In addition to these cancer cell-intrinsic functions, Wnt signaling …

Targeted therapies and immunotherapies have improved the clinical outcome of cancer
patients; however, the efficacy of treatment remains frequently limited due to low …