Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture
of how MHC class I and MHC class II molecules really work. This is a story of the proteases …

Background Knowledge about and identification of T cell tumor antigens may inform the
development of T cell receptor-engineered adoptive cell transfer or personalized cancer …

Simple Summary A new class of drugs, termed Immune Checkpoint Inhibitors, has
revolutionized cancer therapy during the last few years. Unfortunately, these drugs are only …

Cryptic MHC I-associated peptides (MAPs) are produced via two mechanisms: translation of
protein-coding genes in non-canonical reading frames and translation of allegedly non …

Loading of MHC-I molecules with peptide by the catalytic chaperone tapasin in the peptide
loading complex plays a critical role in antigen presentation and immune recognition …

Adaptive immunity is shaped by a selection of peptides presented on major
histocompatibility complex class I (MHC I) molecules. The chaperones Tapasin (Tsn) and …

Central to CD8+ T cell–mediated immunity is the recognition of peptide–major
histocompatibility complex class I (p–MHC I) proteins displayed by antigen-presenting cells …

Immunological chaperones tapasin and TAP binding protein, related (TAPBPR) play key
roles in antigenic peptide optimization and quality control of nascent class I major …

Adaptive immunity depends on cell surface presentation of antigenic peptides by major
histocompatibility complex class I (MHC I) molecules and on stringent ER quality control in …

Peptides presented on MHC I molecules allow the immune system to detect diseased cells.
The displayed peptides typically stem from proteasomal degradation of cytoplasmic proteins …