The formation of protein complexes is crucial to most biological functions. The cellular
mechanisms governing protein complex biogenesis are not yet well understood, but some …

The endoplasmic reticulum represents the gateway to the secretory pathway. Here, proteins
destined for secretion, as well as soluble and membrane proteins that reside in the …

The nascent polypeptide–associated complex (NAC) interacts with newly synthesized
proteins at the ribosomal tunnel exit and competes with the signal recognition particle (SRP) …

Shwachman-Diamond syndrome is a rare inherited bone marrow failure syndrome
characterized by neutropenia, exocrine pancreatic insufficiency, and skeletal abnormalities …

The endoplasmic reticulum (ER) is a major site for protein synthesis, folding, and maturation
in eukaryotic cells, responsible for production of secretory proteins and most integral …

Fidelity of protein targeting is essential for the proper biogenesis and functioning of
organelles. Unlike replication, transcription and translation processes, in which multiple …

Inherited bone marrow failure syndromes (IBMFSs) include Fanconi anemia, Diamond–
Blackfan anemia, Shwachman–Diamond syndrome, dyskeratosis congenita, severe …

Looking at the variety of the thousands of different polypeptides that have been focused on
in the research on the endoplasmic reticulum from the last five decades taught us one …

The eukaryotic signal recognition particle (SRP) cotranslationally recognizes the first
hydrophobic segment of nascent secretory and membrane proteins and delivers them to a …

The signal recognition particle (SRP) is a critical component in protein sorting pathways in
all domains of life. Human SRP contains six proteins bound to the 7S RNA and their …