Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

The Aurora kinase A (AURKA) is involved in different aspects of mitotic control, from mitotic
entry to cytokinesis. Consistent with its pleiotropic roles, several AURKA interactors are able …

Commitment to mitosis must be tightly coordinated with DNA replication to preserve genome
integrity. While we have previously established that the timely activation of CyclinB1-Cdk1 in …

Regulated protein-protein interactions are critical for cell signaling, differentiation, and
development. For the study of dynamic regulation of protein interactions in vivo, there is a …

Abstract Two Cu (II)(C1) and Ni (II)(C2) complexes were designed through the one-pot
reaction of pyridine-2, 6-dicarboxylic acid and 2-aminobenzimidazole respectively with …

Mitosis is induced by the activation of the cyclin B/cdk1 feedback loop that creates a bistable
state. The triggering factor promoting active cyclin B/cdk1 switch has been assigned to cyclin …

The nuclear envelope, which protects and organizes the genome, is dismantled during
mitosis. In the Caenorhabditis elegans zygote, nuclear envelope breakdown (NEBD) of the …

In animal cells, nuclear envelope breakdown (NEBD) is required for proper chromosome
segregation. Whereas mitotic kinases have been implicated in NEBD, how they coordinate …

It is well established that Aurora kinases perform critical functions during mitosis. It has
become increasingly clear that the Aurora kinases also perform a myriad of non-mitotic …

During animal development, a single fertilized egg forms a complete organism with tens to
trillions of cells that encompass a large variety of cell types. Cell cycle regulation is therefore …