Synchronous rhythms represent a core mechanism for sculpting temporal coordination of
neural activity in the brain-wide network. This review focuses on oscillations in the cerebral …

Gamma oscillations appear to be dependent on inhibitory neurotransmission from
parvalbumin (PV)-containing gamma-amino butyric acid neurons. Thus, the abnormalities in …

Anti-N-methyl D-aspartate receptor (NMDAR) encephalitis is a severe neuropsychiatric
disorder that associates with prominent memory and behavioural deficits. Patients' …

Cortical GABAergic dysfunction may underlie the pathophysiology of psychiatric disorders,
including schizophrenia. Here, we characterized a mouse strain in which the essential NR1 …

Although glutamate was first hypothesized to be involved in the pathophysiology of
schizophrenia in the 1980s, it was the demonstration that N-methyl-D-aspartate (NMDA) …

Hypofunction of N-methyl-d-aspartic acid-type glutamate receptors (NMDAR) induced by the
systemic administration of NMDAR antagonists is well known to cause schizophrenia-like …

1. After 50 years of antipsychotic drug development focused on the dopamine D2 receptor,
schizophrenia remains a chronic, disabling disorder for most affected individuals. 2. Studies …

While the dopamine hypothesis has dominated schizophrenia research for several decades,
more recent studies have highlighted the role of fast synaptic transmitters and their receptors …

In subjects with schizophrenia, impairments in working memory are associated with
dysfunction of the dorsolateral prefrontal cortex (DLPFC). This dysfunction appears to be …

Numerous clinical studies demonstrate that subanesthetic doses of dissociative anesthetics,
which are noncompetitive antagonists at the NMDA receptor, replicate in normal subjects the …