Cell fusion is a physiological cellular process essential for fertilization, viral entry, muscle
differentiation and placental development, among others. In this review, we will highlight the …

The main roles of placentas include physical protection, nutrient and oxygen import, export
of gasses and fetal waste products, and endocrinological regulation. In addition to physical …

Several reports claim that the purported similarity between syncytin-1 and the SARS-CoV-2
spike protein may induce immune cross-reactivity resulting in female sterility. We used …

Human endogenous retroviruses (HERVs) comprise nearly 8% of the human genome and
are derived from ancient integrations of retroviruses into the germline. The biology of HERVs …

ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a massive impact on human …

Generation of osteoclasts through fusion of mono-nucleated precursors is a key event of
bone physiology and bone resorption is inefficient without osteoclast fusion. Several factors …

Bone-resorbing multinucleated osteoclasts that play a central role in the maintenance and
repair of our bones are formed from bone marrow myeloid progenitor cells by a complex …

While common in viral infections and neoplasia, spontaneous cell-cell fusion, or
syncytialization, is quite restricted in healthy tissues. Such fusion is essential to human …

Fusion of cytotrophoblasts into the multinucleated syncytiotrophoblast layer is essential for
the development of a functional placenta. The envelope protein of a human endogenous …

Syncytin 2 is a newly identified placental membrane protein with fusogenic and
immunosuppressive activities. Major facilitator superfamily domain containing 2A (MFSD2A) …