Rasagiline mesylate (RSM) is a hydrophilic drug with poor oral bioavailability (36%)
because of hepatic first-pass metabolism. The present study focuses on delivering RSM …

Chemically induced proximity modalities such as targeted protein degradation (TPD) hold
promise for expanding the number of proteins that can be manipulated pharmacologically …

Propargylamine is a chemical moiety whose properties have made it a widely distributed
group within the fields of medicinal chemistry and chemical biology. Its particular reactivity …

The multifactorial origin and neurochemistry of Alzheimer's disease (AD) call for the
development of multitarget treatment strategies. We report a first-in-class triple acting …

Neurodegenerative diseases (NDs) are described as multifactorial and progressive
syndromes with compromised cognitive and behavioral functions. The multi-target-directed …

We present the design, synthesis and biological activity of novel N-substituted
benzimidazole based acrylonitriles as potential tubulin polymerization inhibitors. Their …

Although COVID-19 has been primarily associated with pneumonia, recent data show that
its causative agent, the SARS-CoV-2 coronavirus, can infect many vital organs beyond the …

We describe the synthesis of novel unsubstituted and N-substituted imidazo [4, 5-b] pyridine
derived acrylonitriles, which were prepared by classical and microwave assisted organic …

Harmicines constitute novel hybrid compounds that combine two agents with reported
antiplasmodial properties, namely β-carboline harmine and a cinnamic acid derivative …

We report multifunctional D-π-A molecular systems having the N, N-diethylamino group as a
pH sensitive donor unit connected to the electron accepting substituents such as the cyano …