Targeted therapy for head and neck cancer: signaling pathways and clinical studies

Q Li, Y Tie, A Alu, X Ma, H Shi - Signal transduction and targeted …, 2023 - nature.com
Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

Mechanisms of resistance to photodynamic therapy

A Casas, G Di Venosa, T Hasan… - Current medicinal …, 2011 - ingentaconnect.com
Photodynamic therapy (PDT) involves the administration of a photosensitizer (PS) followed
by illumination with visible light, leading to generation of reactive oxygen species. The …

[HTML][HTML] Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2

CE Eyler, Q Wu, K Yan, JM MacSwords… - Cell, 2011 - cell.com
Malignant gliomas are aggressive brain tumors with limited therapeutic options, and
improvements in treatment require a deeper molecular understanding of this disease. As in …

iNOS promotes CD24+CD133+ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway

R Wang, Y Li, A Tsung, H Huang… - Proceedings of the …, 2018 - National Acad Sciences
The inducible nitric oxide synthase (iNOS) is associated with more aggressive solid tumors,
including hepatocellular carcinoma (HCC). Notch signaling in cancer stem cells promotes …

Recent advances in delivery of drug–nucleic acid combinations for cancer treatment

J Li, Y Wang, Y Zhu, D Oupický - Journal of controlled release, 2013 - Elsevier
Cancer treatment that uses a combination of approaches with the ability to affect multiple
disease pathways has been proven highly effective in the treatment of many cancers …

Targeted Inhibition of Inducible Nitric Oxide Synthase Inhibits Growth of Human Melanoma In vivo and Synergizes with Chemotherapy

AG Sikora, A Gelbard, MA Davies, D Sano… - Clinical cancer …, 2010 - AACR
Purpose: Aberrant expression of inflammatory molecules, such as inducible nitric oxide (NO)
synthase (iNOS), has been linked to cancer, suggesting that their inhibition is a rational …

Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics

S Siemer, D Westmeier, M Barz, J Eckrich, D Wünsch… - Biomaterials, 2019 - Elsevier
Multidrug-resistant bacterial infections are a global health threat. Nanoparticles are thus
investigated as novel antibacterial agents for clinical practice, including wound dressings …

Nanosized food additives impact beneficial and pathogenic bacteria in the human gut: a simulated gastrointestinal study

S Siemer, A Hahlbrock, C Vallet, DJ McClements… - npj Science of …, 2018 - nature.com
Nanotechnology provides the food industry with new ways to modulate various aspects of
food. Hence, engineered nanoparticles (NPs) are increasingly added to food and beverage …

Microtubule‐binding proteins as promising biomarkers of paclitaxel sensitivity in cancer chemotherapy

S Xie, A Ogden, R Aneja, J Zhou - Medicinal research reviews, 2016 - Wiley Online Library
Microtubules, tirelessly animated and highly dynamic structures, are vital for most cellular
processes and their intricacies are still being revealed even after a century since their …

Nanoparticle binding attenuates the pathobiology of gastric cancer-associated Helicobacter pylori

D Westmeier, G Posselt, A Hahlbrock, S Bartfeld… - Nanoscale, 2018 - pubs.rsc.org
Enteric bacteria may cause severe diseases, including gastric cancer-associated
Helicobacter pylori. Their infection paths overlap with the oro-gastrointestinal uptake route …