Cancer is considered as one of the most challenging health care problems. Though there
are many approved drugs that can be used for cancer therapy, drug resistance and delivery …

As chondrocytes from osteoarthritic cartilage usually exhibit aging and senescent
characteristics, targeting aging chondrocytes could be a potential therapeutic strategy. In this …

Most cancers evolve to disable the p53 pathway, a key tumour suppressor mechanism that
prevents transformation and malignant cell growth. However, only~ 50% exhibit inactivating …

A wide range of diseases have been shown to be influenced by the accumulation of
senescent cells, from fibrosis to diabetes, cancer, Alzheimer's and other age-related …

Tumor microenvironment (TME) plays a crucial role in the initiation and progression of lung
adenocarcinoma (LUAD); however, there is still a challenge in understanding the dynamic …

Colorectal cancer liver metastasis (CRCLM) has two major histopathological growth
patterns: angiogenic desmoplastic and non-angiogenic replacement. The replacement …

Resveratrol is one of the most promising phytoalexins for use as an anti‑cancer agent, which
is present in the skin of red grapes and berries. Resveratrol has been demonstrated to …

Reactive oxygen species (ROS) induce multiple signaling cascades in the cell and hence
play an important role in the regulation of the cell's fate. ROS can cause irreversible damage …

Radiotherapy is still a treatment of choice for many malignancies, often in combination with
other strategies. However, its efficacy is limited by the dose that can be safely administered …

Results The expression of miR-135b-5p and KLF4 was manipulated via transfection. The
changes of proliferation, invasion, migration, viability, cycle and apoptosis of GC cells were …