Novel approaches to the establishment of local microenvironment from resorbable biomaterials in the brain in vitro models

NA Kolotyeva, FN Gilmiyarova, AS Averchuk… - International Journal of …, 2023 - mdpi.com
The development of brain in vitro models requires the application of novel biocompatible
materials and biopolymers as scaffolds for controllable and effective cell growth and …

[HTML][HTML] Binding of α-synuclein to ACO2 promotes progressive mitochondrial dysfunction in Parkinson's disease models

J Jiao, G Gao, J Zhu, C Wang, L Liu, H Yang - Redox Biology, 2024 - Elsevier
The accumulation of α-synuclein (α-syn), a key protein in Parkinson's disease (PD),
contributes to progressive neuronal damage associated with mitochondrial dysfunction and …

HLH-30/TFEB mediates sexual dimorphism in immunity in Caenorhabditis elegans

J Sohn, S Kwon, GY Lee, SS Kim, Y Lee, J Lee… - Autophagy, 2024 - Taylor & Francis
Sexual dimorphism affects various biological functions, including immune responses.
However, the mechanisms by which sex alters immunity remain largely unknown. Using …

Transcriptome analyses reveal molecular mechanisms of novel compound heterozygous ACO2 variants causing infantile cerebellar retinal degeneration

W Yang, S Wang, K Yang, Y Li, Z Guo… - Frontiers in Cellular …, 2024 - frontiersin.org
Background and purpose Infantile cerebellar retinal degeneration (ICRD)(OMIM# 614559) is
a rare autosomal recessive inherited disease associated with mutations in the aconitase 2 …