A review: Pharmacological aspects of metal based 1, 2, 4-triazole derived Schiff bases
Clinical reports have highlighted the radical increase of antibiotic resistance. As a result,
multidrug resistance has emerged as a serious threat to human health. Many organic …
multidrug resistance has emerged as a serious threat to human health. Many organic …
Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: three for the price of one
CT Supuran, V Alterio, A Di Fiore… - Medicinal Research …, 2018 - Wiley Online Library
Human carbonic anhydrase (CA) IX is a tumor‐associated protein, since it is scarcely
present in normal tissues, but highly overexpressed in a large number of solid tumors, where …
present in normal tissues, but highly overexpressed in a large number of solid tumors, where …
Carbonic anhydrase IX: a new druggable target for the design of antitumor agents
JY Winum, M Rami, A Scozzafava… - Medicinal research …, 2008 - Wiley Online Library
Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) are a family of enzymes widespread in all
life kingdoms. In mammals, isozyme CA IX is highly overexpressed in many cancer types …
life kingdoms. In mammals, isozyme CA IX is highly overexpressed in many cancer types …
Identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: indolenyl sulfonamide derivatives
Synthesis of seven new indolenyl sulfonamides, have been prepared by the condensation
reaction of indole-3-carboxaldehyde with different sulfonamides such as, sulphanilamide …
reaction of indole-3-carboxaldehyde with different sulfonamides such as, sulphanilamide …
Carbonic anhydrase inhibitors and activators and their use in therapy
A Scozzafava, A Mastrolorenzo… - Expert Opinion on …, 2006 - Taylor & Francis
Among the 16 different α-carbonic anhydrase (CA, EC 4.2. 1.1) isoforms isolated in
mammals, 13 possess catalytic activity for the reversible hydration of carbon dioxide to …
mammals, 13 possess catalytic activity for the reversible hydration of carbon dioxide to …
An update on natural occurrence and biological activity of chromones
The chemistry of chromones is very well known. This system is widely used in organic
chemistry as an intermediate compound for the synthesis of numerous hetrocycles. On the …
chemistry as an intermediate compound for the synthesis of numerous hetrocycles. On the …
sulfonamides
CT Supuran - Molecules, 2017 - mdpi.com
The sulfonamides and their structurally related derivatives, such as the sulfamates and
sulfamides, possess the general formula A-SO2NHR, in which the functional group is either …
sulfamides, possess the general formula A-SO2NHR, in which the functional group is either …
Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs
SLC-0111 is a sulfonamide carbonic anhydrase (CA, EC 4.2. 1.1) inhibitor (CAI) in Phase I/II
clinical trials for the treatment of advanced hypoxic tumors complicated with metastases. Its …
clinical trials for the treatment of advanced hypoxic tumors complicated with metastases. Its …
Metal‐based antibacterial and antifungal amino acid derived Schiff bases: their synthesis, characterization and in vitro biological activity
A new series of antibacterial and antifungal amino acid derived Schiff bases and their cobalt
(II), copper (II), nickel (II) and zinc (II) metal complexes have been synthesized and …
(II), copper (II), nickel (II) and zinc (II) metal complexes have been synthesized and …
Recent updates on the synthesis of bioactive quinoxaline-containing sulfonamides
Quinoxaline is a privileged pharmacophore that has broad-spectrum applications in the
fields of medicine, pharmacology and pharmaceutics. Similarly, the sulfonamide moiety is of …
fields of medicine, pharmacology and pharmaceutics. Similarly, the sulfonamide moiety is of …