Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Neurons are among the most compartmentalized and interactive of all cell types. Like all
cells, neurons use proteins as the main sensors and effectors. The modification of the …

Neurons localize mRNAs near synapses where their translation can be regulated by
synaptic demand and activity. Differences in the 3′ UTRs of mRNAs can change their …

Local translation meets protein turnover and plasticity demands at synapses, however, the
location of its energy supply is unknown. We found that local translation in neurons is …

To form synaptic connections and store information, neurons continuously remodel their
proteomes. The impressive length of dendrites and axons imposes logistical challenges to …

To supply proteins to their vast volume, neurons localize mRNAs and ribosomes in dendrites
and axons. While local protein synthesis is required for synaptic plasticity, the abundance …

Coronaviruses (CoVs) assemble by budding into the lumen of the intermediate compartment
(IC) at the endoplasmic reticulum (ER)-Golgi interface. However, why CoVs have chosen the …

Efficient neuronal function depends on the continued modulation of the local neuronal
proteome. Local protein synthesis plays a central role in tuning the neuronal proteome at …

Neurons face the challenge of regulating the abundance, distribution and repertoire of
integral membrane proteins within their immense, architecturally complex dendritic arbors …

Genetic studies have demonstrated that conditional ablation of core autophagy genes in the
neural lineage leads to progressive neurodegeneration, indicating that this catabolic …