Paracetamol use during pregnancy—a call for precautionary action

AZ Bauer, SH Swan, D Kriebel, Z Liew… - Nature Reviews …, 2021 - nature.com
Abstract Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise known as
acetaminophen) is the active ingredient in more than 600 medications used to relieve mild to …

Environmental exposures associated with elevated risk for autism spectrum disorder may augment the burden of deleterious de novo mutations among probands

K Pugsley, SW Scherer, MA Bellgrove, Z Hawi - Molecular psychiatry, 2022 - nature.com
Although the full aetiology of autism spectrum disorder (ASD) is unknown, familial and twin
studies demonstrate high heritability of 60–90%, indicating a predominant role of genetics in …

[HTML][HTML] Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis …

S Alemany, C Avella-García, Z Liew… - European journal of …, 2021 - Springer
The potential etiological role of early acetaminophen exposure on Autism Spectrum
Conditions (ASC) and Attention-Deficit/Hyperactivity Disorder (ADHD) is inconclusive. We …

Association of mitochondrial DNA content, heteroplasmies and inter-generational transmission with autism

Y Wang, X Guo, X Hong, G Wang, C Pearson… - Nature …, 2022 - nature.com
Mitochondria are essential for brain development. While previous studies linked
dysfunctional mitochondria with autism spectrum disorder (ASD), the role of the …

Boston Birth Cohort profile: rationale and study design

C Pearson, T Bartell, G Wang, X Hong, SA Rusk… - Precision …, 2022 - journals.lww.com
Abstract In1998, the Boston Birth Cohort (BBC) was initiated at Boston Medical Center
(BMC) in response to persistently high rates of preterm birth (PTB, defined as birth before 37 …

Paracetamol (acetaminophen) and the developing brain

C Bührer, S Endesfelder, T Scheuer… - International journal of …, 2021 - mdpi.com
Paracetamol is commonly used to treat fever and pain in pregnant women, but there are
growing concerns that this may cause attention deficit hyperactivity disorder and autism …

Repeated measurements of 21 urinary metabolites of volatile organic compounds and their associations with three selected oxidative stress biomarkers in 0− 7-year …

W Song, Q Han, Y Wan, X Qian, M Wei, Y Jiang… - Chemosphere, 2022 - Elsevier
Human beings are extensively and concurrently exposed to multiple volatile organic
compounds (VOCs, including some Class I human carcinogens), which may induce …

Fever during pregnancy as a risk factor for neurodevelopmental disorders: results from a systematic review and meta-analysis

S Antoun, P Ellul, H Peyre, M Rosenzwajg, P Gressens… - Molecular autism, 2021 - Springer
Background Fever during pregnancy is a relatively common and most often trivial event.
However, under specific conditions, it could affect significantly fetal brain development. Few …

The main changes in pregnancy—therapeutic approach to musculoskeletal pain

F Fiat, PE Merghes, AD Scurtu, B Almajan Guta… - Medicina, 2022 - mdpi.com
Background and Objectives: During pregnancy, women undergo various physiological and
anatomical changes that are accentuated as the pregnancy progresses, but return to their …

Association of prenatal acetaminophen exposure measured in meconium with risk of attention-deficit/hyperactivity disorder mediated by frontoparietal network brain …

BH Baker, C Lugo-Candelas, H Wu, HE Laue… - JAMA …, 2020 - jamanetwork.com
Importance Despite evidence of an association between prenatal acetaminophen exposure
and attention-deficit/hyperactivity disorder (ADHD) in offspring, the drug is not …