The synthesis and evaluation of small-molecule inhibitors of tubulin polymerization remains
a promising approach for the development of new therapeutic agents for cancer treatment …

In this work, a series of new diarylpyrimidine derivatives as microtubule destabilizers were
designed, synthesized, and evaluated for anticancer activities. Based on restriction …

Strigolactones (SLs) are plant hormones that regulate several key agronomic traits,
including shoot branching, leaf senescence, and stress tolerance. The artificial regulation of …

A series of new tubulin inhibitors containing chalcogen bonds have been discovered.
Density functional theory (DFT) analysis of the O–C–C–S torsion profile shows a preference …

Microtubules play an indispensable role in numerous cellular processes. Targeting the
colchicine binding site on tubulin to destabilize microtubules is a promising strategy for …

Chlamydiae are obligate intracellular Gram-negative bacteria and widespread pathogens in
humans and animals. Broad-spectrum antibiotics are currently used to treat chlamydial …

Hepatocellular carcinoma (HCC) is considered one of the most common primary liver
cancers and the second leading cause of cancer‐associated mortality around the world …

Microtubules play an indispensable role in numerous cellular processes. Targeting
colchicine binding site to destabilize microtubules is a promising strategy for cancer …