PPARγ and the Innate Immune System Mediate the Resolution of Inflammation

A Croasdell, PF Duffney, N Kim, SH Lacy… - PPAR …, 2015 - Wiley Online Library
The resolution of inflammation is an active and dynamic process, mediated in large part by
the innate immune system. Resolution represents not only an increase in anti‐inflammatory …

The role of PPAR-γ in allergic disease

JM Stark, JM Coquet, CA Tibbitt - Current Allergy and Asthma Reports, 2021 - Springer
Abstract Purpose of Review The incidence of allergic diseases such as asthma, rhinitis and
atopic dermatitis has risen at an alarming rate over the last century. Thus, there is a clear …

Can pioglitazone be potentially useful therapeutically in treating patients with COVID-19?

E Carboni, AR Carta, E Carboni - Medical Hypotheses, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a
pandemic disease (COVID-19) that has spread globally causing more than 30,000 deaths …

[HTML][HTML] Regulation and deregulation of cholesterol homeostasis: The liver as a metabolic “power station”

L Trapani, M Segatto, V Pallottini - World journal of hepatology, 2012 - ncbi.nlm.nih.gov
Cholesterol plays several structural and metabolic roles that are vital for human biology. It
spreads along the entire plasma membrane of the cell, modulating fluidity and concentrating …

PPAR gamma: from definition to molecular targets and therapy of lung diseases

MV Carvalho, CF Gonçalves-de-Albuquerque… - International Journal of …, 2021 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor
superfamily that regulate the expression of genes related to lipid and glucose metabolism …

The emerging role for metabolism in fueling neutrophilic inflammation

T Morrison, ER Watts, P Sadiku… - Immunological …, 2023 - Wiley Online Library
Neutrophils are a critical element of host defense and are rapidly recruited to inflammatory
sites. Such sites are frequently limited in oxygen and/or nutrient availability, presenting a …

Treating viral exacerbations of chronic obstructive pulmonary disease: insights from a mouse model of cigarette smoke and H1N1 influenza infection

CMT Bauer, CCJ Zavitz, FM Botelho, KN Lambert… - PloS one, 2010 - journals.plos.org
Background Chronic obstructive pulmonary disease is a progressive lung disease that is
punctuated by periods of exacerbations (worsening of symptoms) that are attributable to viral …

Down-regulated peroxisome proliferator-activated receptor γ (PPARγ) in lung epithelial cells promotes a PPARγ agonist-reversible proinflammatory phenotype in …

SP Lakshmi, AT Reddy, Y Zhang, FC Sciurba… - Journal of Biological …, 2014 - ASBMB
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory condition and
a leading cause of death, with no available cure. We assessed the actions in pulmonary …

Endothelial PPARγ is crucial for averting age-related vascular dysfunction by stalling oxidative stress and ROCK

MS Uddin, MT Kabir, M Jakaria, AA Mamun… - Neurotoxicity …, 2019 - Springer
Aging plays a significant role in the progression of vascular diseases and vascular
dysfunction. Activation of the ADP-ribosylation factor 6 and small GTPases by inflammatory …

Influenza virus causes lung immunopathology through down-regulating PPARγ activity in macrophages

H Zhang, T Alford, S Liu, D Zhou, J Wang - Frontiers in Immunology, 2022 - frontiersin.org
Fatal influenza (flu) virus infection often activates excessive inflammatory signals, leading to
multi-organ failure and death, also referred to as cytokine storm. PPARγ (Peroxisome …